Coleus Forskohlii-the only plant source of forskohlin
 
 
  Coleus Forskohlii-the only plant source of forskohlin
     
 
  • Coleus forskohlii Briq. (synonyms, C. barbatus Benth., Plectranthus forskohlii Willd., P. barbatus Andr. and P. comosus Willemse) a member of the mint family (fam. Lamiaceae), is indigenous to Ayurvedic Medicine.

  • This species is a perennial herb with fleshy, fibrous roots that grows wild in the warm subtropical temperate areas in India, Burma and Thailand.

  • In India, it is cultivated for use as a condiment1.

  • In recent years, Coleus forskohlii has gained recognition As the only known plant source of the diterpene, Forskohlin2.

  • forskohlin is valued as an adenylate cyclase activator.

  • Adenylate cyclase is the enzyme involved in the production of Cyclic Adenosine Monophosphate (cAMP), (a significant biochemical agent involved in metabolic processes), from the high energy molecule, ATP (Adenosine triphosphate).

  • Nicknamed in literature as a "second messenger," cyclic AMP facilitates the action of "primary messengers" or various hormonal and bioactive substances in the body.

    • The role of cyclic AMP is indispensable to many body functions.

    • Cyclic AMP induces a chain of biochemical events that trigger metabolic processes and diet induced thermogenesis3, thereby providing the means to maintain a healthy body composition and lean body mass levels.
 
     
 

References

  1. Bruneton, Jean. (1995) Coleus forskohlii in Pharmacognosy, Phytochemistry, Medicinal Plants, Lavoisier Publishing Company, 521.

  2. de Souza, N.J. (1991) Coleus forskohlii Briq.- The Indian plant source for forskohlin. Recent Advances in Medicinal, Aromatic & Spice crops, (ed: S..P. Raychaudhuri.) Today and Tomorrow's printers and Publishers, New Delhi, India, Vol I: 83-91.

  3. Palou, A. , et al. (1998) The uncoupling protein, thermogenin. Int. J. Biochem. Cell Biol., 30(1):7-11.

 
     
 
 

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